The city's Health Department has confirmed its first case of enterovirus 68.
Officials say a child in New York City has been diagnosed, along with an elementary school student on Long Island. There is no word yet on either of their conditions.
The uncommon illness can cause severe respiratory problems, especially in children. Health officials are keeping an eye out for kids admitted to the hospital who show symptoms.
New Yorkers are reminded that the best way to stop the spread of the infectious disease is by simply washing your hands. There is no vaccine to prevent the illness, but most patients recover without treatment.
At least 130 cases have been confirmed nationwide, the worst needing life support for breathing difficulties, but no deaths have been reported.